bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

Base Information

Chemical Name:bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate
CAS No.:1246610-02-5
Molecular Formula:C₄₂H₅₈N₈O₆
Molecular Weight:770.973
Hs Code.:

Synonyms:bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

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Chemical Property of bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

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Technology Process of bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

There total 8 articles about bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027511-51-8
di(tert-butyl) [5-(aminomethyl)pyridin-2-yl]imidodicarbonate

: C₃₀H₃₈N₆O₅

: 1246610-02-5
bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 1246610-02-5
bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 48 h / 20 °C

2.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

2.2: Cooling with ice

3.1: ethanol / 24 h / Reflux

4.1: sodium hydroxide; ethanol / 2 h / 20 °C

4.2: pH 5

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

7.1: dmap / tetrahydrofuran / 0.25 h / 20 °C

8.1: dmap; triethylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; dmap; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 3.1: Bohlman-Rahtz Reaction;

Reference yield:

: 304873-79-8
tert-butyl ((1s,4s)-4-(methoxy(methyl)carbamoyl)cyclohexyl)carbamate

: 1246610-02-5
bis-tert-butyl (1s,4s)-4-(6-(phenylamino)-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

1.2: Cooling with ice

2.1: ethanol / 24 h / Reflux

3.1: sodium hydroxide; ethanol / 2 h / 20 °C

3.2: pH 5

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 24 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: dmap / tetrahydrofuran / 0.25 h / 20 °C

7.1: dmap; triethylamine / tetrahydrofuran / 3 h / 20 °C

With hydrogenchloride; dmap; ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 2.1: Bohlman-Rahtz Reaction;