6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

Base Information

Chemical Name:6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid
CAS No.:1246609-99-3
Molecular Formula:C₂₃H₂₉N₃O₄
Molecular Weight:411.501
Hs Code.:

Synonyms:6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

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Chemical Property of 6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

Chemical Property:

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Technology Process of 6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

There total 5 articles about 6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246609-98-2
ethyl 6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinate

: 1246609-99-3
6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

Guidance literature:: ethyl 6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinate; With ethanol; sodium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 53292-90-3
cis-4-tert-butoxycarbonylaminocyclohexane-1-ylcarboxylic acid

: 1246609-99-3
6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 48 h / 20 °C

2.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

2.2: Cooling with ice

3.1: ethanol / 24 h / Reflux

4.1: sodium hydroxide; ethanol / 2 h / 20 °C

4.2: pH 5

With ethanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; 3.1: Bohlman-Rahtz Reaction;

Reference yield:

: 304873-79-8
tert-butyl ((1s,4s)-4-(methoxy(methyl)carbamoyl)cyclohexyl)carbamate

: 1246609-99-3
6-((1s,4s)-4-(tert-butoxycarbonylamino)cyclohexyl)-2-(phenylamino)nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate; tetrahydrofuran / 4 h / 0 °C

1.2: Cooling with ice

2.1: ethanol / 24 h / Reflux

3.1: sodium hydroxide; ethanol / 2 h / 20 °C

3.2: pH 5

With ethanol; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; 2.1: Bohlman-Rahtz Reaction;