2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

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Chemical Name:2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol
CAS No.:1615683-42-5
Molecular Formula:C₁₈H₁₆FN₅O₃
Molecular Weight:369.355
Hs Code.:

Synonyms:2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

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Chemical Property of 2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

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Technology Process of 2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

There total 5 articles about 2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1052686-59-5
2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1193244-89-1
5-bromo-2-(1-hydroxy-1-methylethyl)pyrimidine

: 1615683-42-5
2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;
DOI:10.1021/jm500563g

Reference yield:

: 1073354-10-5
2,2-dimethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propionamide

: 1615683-42-5
2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C

2.1: bromine; sodium acetate / acetic acid

2.3: Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.022

Reference yield:

: 797047-16-6
2,2-dimethyl-N-(2-pyrimidin-2-yl-phenyl)-propionamide

: 1615683-42-5
2-(5-(4-amino-3-(3-fluoropyridin-2-yl)-5-nitrophenyl)-pyrimidin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; sodium acetate / acetic acid

1.3: Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; sodium carbonate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.022