Fmoc-cis-DL-3-phenyl-Pro-OH

Base Information

Chemical Name:Fmoc-cis-DL-3-phenyl-Pro-OH
CAS No.:181824-45-3
Molecular Formula:C₂₆H₂₃NO₄
Molecular Weight:413.473
Hs Code.:29339900
DSSTox Substance ID:DTXSID60373287
Wikidata:Q82161442
Mol file:181824-45-3.mol

Synonyms:Fmoc-cis-DL-3-phenyl-Pro-OH;181824-45-3;Racemic Fmoc-cis-3-phenyl-pyrrolidine-2-carboxylic acid;(2S,3S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid;(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-3-phenylpyrrolidine-2-carboxylic acid;1158891-09-8;SCHEMBL1675971;DTXSID60373287;MFCD06656478;AKOS025404011;E70731;EN300-7418875;rac-Fmoc-cis-3-Phenyl-pyrrolidine-2-carboxylic acid;cis-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-phenyl-2-pyrrolidinecarboxylic acid;rac-(2R,3R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-3-phenylpyrrolidine-2-carboxylic acid;rel-(2S,3S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-3-phenylpyrrolidine-2-carboxylic acid

Suppliers and Price of Fmoc-cis-DL-3-phenyl-Pro-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Racemic Fmoc-cis-3-phenyl-pyrrolidine-2-carboxylic acid
250mg
$ 372.00

Iris Biotech GmbH
Fmoc-cis-Pro(3-Ph)-OH(rac)
5 g
$ 810.00

Crysdot
racemicFmoc-cis-3-phenyl-pyrrolidine-2-carboxylicacid 95+%
5g
$ 815.00

AK Scientific
Racemicfmoc-cis-3-phenyl-pyrrolidine-2-carboxylicacid
250mg
$ 266.00

Total 4 raw suppliers

Chemical Property of Fmoc-cis-DL-3-phenyl-Pro-OH

Chemical Property:

Boiling Point:626.3±55.0 °C(Predicted)
PKA:3.79±0.40(Predicted)
PSA：66.84000
Density:1.299±0.06 g/cm3(Predicted)
LogP:4.81610
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:413.16270821
Heavy Atom Count:31
Complexity:638

Purity/Quality:

99% ^*data from raw suppliers

Racemic Fmoc-cis-3-phenyl-pyrrolidine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(C1C2=CC=CC=C2)C(=O)O)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
Isomeric SMILES:C1CN([C@@H]([C@@H]1C2=CC=CC=C2)C(=O)O)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

Technology Process of Fmoc-cis-DL-3-phenyl-Pro-OH

There total 2 articles about Fmoc-cis-DL-3-phenyl-Pro-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 118758-48-8
(2S,3R)-3-phenyl-pyrrolidine-2-carboxylic acid

: 281655-32-1,181824-45-3
(2S,3R)-3-phenyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 18.0833h;
DOI:10.1016/j.bmc.2011.08.020

Reference yield: 64.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: (2S,3S)-3-phenyl-1-pivaloylpyrrolidine-2-carboxylic acid trifluoroacetic acid salt

: 181824-45-3
C₂₆H₂₃NO₄

Guidance literature:: With sodium carbonate; In water; acetone;
DOI:10.1021/acs.jmedchem.0c01941

Reference yield: 42.0%

: 181824-45-3
cis-N-Fmoc-3-phenylpyrrolidine-2-carboxylicacid

: 35661-40-6
N-Fmoc L-Phe

: 1443120-76-0
C₂₀H₂₃N₃O₂

: 1443120-69-1
C₂₀H₂₃N₃O₂

Guidance literature:: cis-N-Fmoc-3-phenylpyrrolidine-2-carboxylicacid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Rink amide MBHA resin

With piperidine; In N,N-dimethyl-formamide; Rink amide MBHA resin

N-Fmoc L-Phe; Further stages;
DOI:10.1021/jm400209h