2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1615201-44-9
Molecular Formula:C₁₇H₁₈N₄O₄S
Molecular Weight:374.42
Hs Code.:

Synonyms:2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1615201-42-7
2-((4-aminophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1615201-44-9
2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 2-((4-aminophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; With hydrogenchloride; sodium nitrite; In ethanol; water; for 0.25h;

With sodium azide; In ethanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2014.05.019

Reference yield:

: 879473-33-3
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-nitrophenyl)sulfonyl]isoquinoline

: 1615201-44-9
2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

2.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h

2.2: 0.5 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sodium nitrite; In ethanol; water;
DOI:10.1016/j.ejmech.2014.05.019

Reference yield:

: 321706-24-5
N-[2-(3,4-dimethoxyphenyl)ethyl]-4-nitrobenzenesulfonamide

: 1615201-44-9
2-((4-azidophenyl)sulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: formic acid / 2 h / 20 °C / Reflux

2.1: tin(II) chloride dihdyrate / ethanol / 4 h / Reflux

3.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.25 h

3.2: 0.5 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; sodium nitrite; In formic acid; ethanol; water; 1.1: |Pictet-Spengler Synthesis;
DOI:10.1016/j.ejmech.2014.05.019