Technology Process of N-(4-methoxybenzyl)-3-oxo-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide
There total 7 articles about N-(4-methoxybenzyl)-3-oxo-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-amino-3-hydroxy-N-(4-methoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide; chloroacetyl chloride;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
In
N,N-dimethyl-formamide;
at 20 - 50 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 3 h
1.2: 1 h / 0 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
2.2: 0.25 h / -78 °C
3.1: sodium trimethylsilanolate / tetrahydrofuran / 0 °C
4.1: acetic acid; iron / tetrahydrofuran / 40 h / Sealed tube; Heating
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere
5.2: 2 h / 20 - 50 °C / Inert atmosphere
With
triisopropoxytitanium(IV) chloride; sodium trimethylsilanolate; iron; potassium carbonate; acetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
1.2: 0.25 h / -78 °C
2.1: sodium trimethylsilanolate / tetrahydrofuran / 0 °C
3.1: acetic acid; iron / tetrahydrofuran / 40 h / Sealed tube; Heating
4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: 2 h / 20 - 50 °C / Inert atmosphere
With
sodium trimethylsilanolate; iron; potassium carbonate; acetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
