rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

Base Information

Chemical Name:rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine
CAS No.:87626-28-6
Molecular Formula:C₂₅H₃₁NO₄
Molecular Weight:409.525
Hs Code.:

Synonyms:rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

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Chemical Property of rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

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Technology Process of rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

There total 6 articles about rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 39053-78-6
3,4,5-trimethoxyphenylacetyl chloride

: 23909-63-9,42529-31-7,60363-12-4,69400-84-6,69400-88-0
rel-(2R,6R,11S)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

: 87626-28-6
rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

Guidance literature:: With sodium carbonate; In chloroform; for 2h; Ambient temperature;
DOI:10.1002/jhet.5570200409

Reference yield:

: 87626-26-4
2-benzyl-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

: 87626-28-6
rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 4 steps

1: 48percent HBr; HCl / Heating

3: 52 percent / cyanogen bromide

4: 79 percent / sodium carbonate decahydrate / CHCl₃ / 2 h / Ambient temperature

With hydrogenchloride; bromocyane; hydrogen bromide; sodium carbonate; In chloroform;
DOI:10.1002/jhet.5570200409

Reference yield:

: 6283-41-6
1,3,4-trimethylpyridinium iodide

: 87626-28-6
rel-(2R,6R,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenylacetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 5 steps

1: 2) sodium borohydride, NaOH / 1) ether; 2) methanol, water

2: 48percent HBr; HCl / Heating

4: 52 percent / cyanogen bromide

5: 79 percent / sodium carbonate decahydrate / CHCl₃ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; bromocyane; hydrogen bromide; sodium carbonate; In chloroform;
DOI:10.1002/jhet.5570200409