rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

Base Information

Chemical Name:rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine
CAS No.:87626-30-0
Molecular Formula:C₂₅H₃₁NO₃
Molecular Weight:393.526
Hs Code.:

Synonyms:

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Chemical Property of rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

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Technology Process of rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

There total 9 articles about rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87626-26-4
2-benzyl-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

: 87626-30-0
rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 6 steps

1: 48percent HBr; HCl / Heating

3: 52 percent / cyanogen bromide

4: 79 percent / sodium carbonate decahydrate / CHCl₃ / 2 h / Ambient temperature

5: 85 percent / lithium aluminum hydride / diethyl ether / 16 h / Heating

6: 1) mercuric acetate; 2) hydrogen sulfide / 1) 10percent aqueous acetic acid, reflux, 7 h; 2) reflux, 45 min

With hydrogenchloride; lithium aluminium tetrahydride; bromocyane; hydrogen sulfide; mercury(II) diacetate; hydrogen bromide; sodium carbonate; In diethyl ether; chloroform;
DOI:10.1002/jhet.5570200409

Reference yield:

: 6283-41-6
1,3,4-trimethylpyridinium iodide

: 87626-30-0
rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 7 steps

1: 2) sodium borohydride, NaOH / 1) ether; 2) methanol, water

2: 48percent HBr; HCl / Heating

4: 52 percent / cyanogen bromide

5: 79 percent / sodium carbonate decahydrate / CHCl₃ / 2 h / Ambient temperature

6: 85 percent / lithium aluminum hydride / diethyl ether / 16 h / Heating

7: 1) mercuric acetate; 2) hydrogen sulfide / 1) 10percent aqueous acetic acid, reflux, 7 h; 2) reflux, 45 min

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; bromocyane; hydrogen sulfide; mercury(II) diacetate; hydrogen bromide; sodium carbonate; In diethyl ether; chloroform;
DOI:10.1002/jhet.5570200409

Reference yield:

: 4-[2-((6R,11R)-6,11-Dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethyl]-2,6-dimethoxy-phenol

: 87626-30-0
rel-(2R,6S,11S)-6,11-dimethyl-3-(3,4,5-trimethoxyphenethyl)-1,2,3,6-tetrahydro-2,6-methano-3-benzazocine

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether

2: 1) mercuric acetate; 2) hydrogen sulfide / 1) 10percent aqueous acetic acid, reflux, 7 h; 2) reflux, 45 min

With hydrogen sulfide; mercury(II) diacetate; In diethyl ether;
DOI:10.1002/jhet.5570200409