((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

Base Information

• Chemical Name: ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate
• CAS No.: 1563184-93-9
• Molecular Formula: C₂₀H₃₁N₃O₁₁S₂
• Molecular Weight: 553.612
• Mol file: 1563184-93-9.mol

Synonyms:((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

Chemical Property of ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

There total 5 articles about ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(bis(2-hydroxyethyl)amino)-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide (1563184-92-8) + methanesulfonyl chloride (124-63-0) → ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate (1563184-93-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

2-fluoro-5-nitrobenzoic acid (7304-32-7) → ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate (1563184-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

1.2: 0.5 h / -10 - 20 °C

2.1: triethylamine / 1,4-dioxane / 55 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;

Reference yield:

2-[(tetrahydropyran-2-yl)oxy]ethylamine (2201-20-9) → ((4-nitro-2-((2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)carbamoyl)phenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate (1563184-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

1.2: 0.5 h / -10 - 20 °C

2.1: triethylamine / 1,4-dioxane / 55 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;

upstream raw materials:

2-(bis(2-hydroxyethyl)amino)-5-nitro-N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzamide

methanesulfonyl chloride

2-fluoro-5-nitrobenzoic acid

2-[(tetrahydropyran-2-yl)oxy]ethylamine

Downstream raw materials:

((2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)azanediyl)bis(ethane-2,1-diyl)dimethanesulfonate

2-((2-bromoethyl)(2-((2-hydroxyethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

2-((2-bromoethyl)(2-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-4-nitrophenyl)amino)ethyl methanesulfonate

2-((2-bromoethyl)(4-nitro-2-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate