ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Chemical Name:ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.:1616491-12-3
Molecular Formula:C₂₂H₂₀INO₆
Molecular Weight:521.308
Hs Code.:

Synonyms:ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Chemical Property of ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

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Technology Process of ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 8 articles about ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1616491-11-2
(Z)-methyl5-(((2-(2-chloro-5-iodobenzoyl)-3-ethoxy-3-oxoprop-1-en-1-yl)amino)methyl)-2-methoxybenzoate

: 1616491-12-3
ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 63113-79-1
methyl 2-methoxy-5-methylbenzoate

: 1616491-12-3
ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Perbenzoic acid; N-Bromosuccinimide / tetrachloromethane / Reflux

2: ammonia / methanol / 2 h / 70 °C

3: ethanol; diethyl ether / 0.25 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

With N-Bromosuccinimide; Perbenzoic acid; ammonia; potassium carbonate; In methanol; tetrachloromethane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.028

Reference yield:

: 900641-76-1
methyl 5-(aminomethyl)-2-methoxybenzoate

: 1616491-12-3
ethyl 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; diethyl ether / 0.25 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 100 °C

With potassium carbonate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.028