(2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

Base Information

• Chemical Name: (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine
• CAS No.: 119751-61-0
• Molecular Formula: C₃₀H₄₆NO₆PSi
• Molecular Weight: 575.758

Synonyms:(2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

Chemical Property of (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

Chemical Property:

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Technology Process of (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

There total 4 articles about (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1.6M-n-butyllithium-hexane + (2S,4R)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-tosyloxypyrrolidine + bis(4-methoxyphenyl)phosphine (84127-04-8) → (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine (119751-61-0)

Guidance literature:

With sodium chloride; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;

Reference yield:

tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate (61478-26-0) → (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine (119751-61-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 2.) 10percent H₂O₂

With dihydrogen peroxide;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (2S,4S)-N-tert.-butoxycarbonyl-2-tert.-butyldimethylsilyloxymethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine (119751-61-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 2.) 10percent H₂O₂

With dihydrogen peroxide;

upstream raw materials:

Lithium-di-(p-anisyl)-phosphid

(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

tert-butyl (2S,4R)-4-hydroxy-2-hydroxymethyl-pyrrolidine-1-carboxylate

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2S,4S)-N-tert.-butoxycarbonyl-4-bis(4-methoxyphenyl)phosphinyl-2-tosyloxymethylpyrrolidine

(2S,4S)-N-tert.-butoxycarbonyl-2-bis(2-methoxyphenyl)phosphinylmethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

(2S,4S)-N-tert.-butoxycarbonyl-2-bis(2-methoxyphenyl)phosphinomethyl-4-bis(4-methoxyphenyl)phosphinopyrrolidine

(2S,4S)-2-bis(2-methoxyphenyl)phosphinylmethyl-4-bis(4-methoxyphenyl)phosphinylpyrrolidine

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