(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate
CAS No.:887917-86-4
Molecular Formula:C₁₈H₁₉NO₄S
Molecular Weight:345.419
Hs Code.:

Synonyms:(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of (2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

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Technology Process of (2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

There total 11 articles about (2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 5535-48-8
PVS

: 66646-88-6
methyl 2-(benzylideneamino)acetate

: 887917-86-4
(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With C₄₄H₃₇FeN₃P₂; copper (I) acetate; In diethyl ether; at -40 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol8003996

Reference yield: 81.0%

: 67-56-1
methanol

: 5535-48-8
PVS

: 1574388-00-3
2-amino-1-(1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)ethanone

: 100-52-7
benzaldehyde

: 887917-86-4
(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: PVS; 2-amino-1-(1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)ethanone; benzaldehyde; With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; In toluene; at 20 ℃; Inert atmosphere; Darkness;

methanol; With dipotassium hydrogenphosphate; at 60 ℃; for 5h; Reagent/catalyst; Solvent;
DOI:10.1021/ol500474a

Reference yield: 72.0%

: 1357917-95-3
(2R,4S,5R)-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-N-methoxy-N-methylcarboxamide

: 887917-86-4
(2R,4S,5R)-(-)-methyl-5-phenyl-4-(phenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With sulfuric acid; In methanol; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Reflux;
DOI:10.1039/c2cc17149j