tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

Base Information

Chemical Name:tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate
CAS No.:1235545-49-9
Molecular Formula:C₂₆H₃₀F₂N₂O₄
Molecular Weight:472.532
Hs Code.:

Synonyms:tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

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Chemical Property of tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

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Technology Process of tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

There total 1 articles about tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1109284-47-0
tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1235545-49-9
tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile; for 1.5h;

Reference yield:

: 1235545-49-9
tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

: 1235545-48-8
(1R,6S)-6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2,2-difluorocyclohexanaminium chloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃;

Reference yield:

: 1235545-49-9
tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate

: 1314893-30-5
N-[(1R,6S)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-ethylthiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 50 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 3 h / 20 °C

3.1: piperidine / N,N-dimethyl-formamide / 4 h / 20 °C

With piperidine; hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;