6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine

Base Information

• Chemical Name: 6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine
• CAS No.: 117491-07-3
• Molecular Formula: C₁₆H₁₇N₃O₄S
• Molecular Weight: 347.395
• Mol file: 117491-07-3.mol

Synonyms:6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine

Chemical Property of 6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine

There total 1 articles about 6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyanothioacetamide (7357-70-2) + 3-(4-nitrobenzylidene)pentane-2,4-dione (29197-16-8) + methyl iodide (74-88-4) → 5-Acetyl-6-methyl-2-methylsulfanyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonitrile (117490-99-0) + 6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine (117491-07-3)

Guidance literature:

With piperidine; Yield given. Multistep reaction. Yields of byproduct given; 1.) EtOH, r.t., 10 min, 2.) r.t., 30 min;

DOI:10.1007/BF00763628

Reference yield: 85.0%

6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine (117491-07-3) → 5-Acetyl-6-methyl-2-methylsulfanyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonitrile (117490-99-0)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.0833333h; Heating;

DOI:10.1007/BF00763628

upstream raw materials:

Cyanothioacetamide

3-(4-nitrobenzylidene)pentane-2,4-dione

methyl iodide

Downstream raw materials:

5-Acetyl-6-methyl-2-methylsulfanyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonitrile