5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

Base Information

• Chemical Name: 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one
• CAS No.: 131890-53-4
• Molecular Formula: C₁₃H₁₃N₅O
• Molecular Weight: 255.279

Synonyms:5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

Chemical Property of 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

Chemical Property:

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Technology Process of 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

There total 2 articles about 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-Methyl-2-methylsulfanyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidine-5-carbonitrile (131890-43-2) → 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one (131890-53-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1016/0223-5234(90)90148-V

Reference yield:

6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile (128666-81-9) → 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one (131890-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / potassium carbonate / dimethylformamide / 4 h / Ambient temperature

2: 65 percent / hydrazine hydrate / ethanol / 2 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(90)90148-V

Reference yield: 66.0%

formic acid (64-18-6) + 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one (131890-53-4) → 6-cyano-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one (131890-67-0)

Guidance literature:

Heating;

DOI:10.1016/0223-5234(90)90148-V

upstream raw materials:

1-Methyl-2-methylsulfanyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidine-5-carbonitrile

6-(4-methylphenyl)3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile

Downstream raw materials:

6-cyano-3-mercapto-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one

6-cyano-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one

5-Amino-1-[5-cyano-4-(3-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid methyl ester

2-acetylhydrazino-5-cyano-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one

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