6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol

Base Information

• Chemical Name: 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol
• CAS No.: 139164-15-1
• Molecular Formula: C₂₅H₃₆O₂Si₂
• Molecular Weight: 424.731
• Mol file: 139164-15-1.mol

Synonyms:6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol

Chemical Property of 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol

There total 7 articles about 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-((tert-butyldiphenylsilyl)oxy)butanal (127793-62-8) + trimethylsilylacetylene (1066-54-2) → 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol (139164-15-1)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

4-((tert-butyldiphenylsilyl)oxy)butanal; In tetrahydrofuran; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4020(00)00865-6

Reference yield: 58.0%

6-Trimethylsilylhex-5-yn-1,4-diol (139055-99-5) + tert-butylchlorodiphenylsilane (58479-61-1) → 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol (139164-15-1)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

DOI:10.1039/P19910003301

Reference yield:

4-(tret-butyldiphenylsilyloxy)butan-1-ol (130372-07-5) → 6-tert-Butyldiphenylsilyloxy-1-trimethylsilylhex-1-yn-3-ol (139164-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 80 percent / potassium acetate; pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.2: 92 percent / tetrahydrofuran / 0.25 h / 0 °C

With n-butyllithium; potassium acetate; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/S0040-4020(00)00865-6

upstream raw materials:

6-Trimethylsilylhex-5-yn-1,4-diol

tert-butylchlorodiphenylsilane

4-((tert-butyldiphenylsilyl)oxy)butanal

trimethylsilylacetylene

Downstream raw materials:

6-(tert-butyldiphenylsilyloxy)-1-(trimethylsilyl)-1-hexyn-3-one

Acetic acid (2R,3S)-2-[5-benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-yl ester

(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol