(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Base Information

Chemical Name:(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol
CAS No.:328382-15-6
Molecular Formula:C₃₇H₄₆O₄Si
Molecular Weight:582.855
Hs Code.:

Synonyms:(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Suppliers and Price of (2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

There total 10 articles about (2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 328382-05-4
Acetic acid (2R,3S)-2-[5-benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-yl ester

: 328382-15-6
(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(00)00865-6

Reference yield:

: 127793-62-8
4-((tert-butyldiphenylsilyl)oxy)butanal

: 328382-15-6
(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 92 percent / tetrahydrofuran / 0.25 h / 0 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: 85 percent / dimethylformamide / 2 h / 20 °C

3.1: 89 percent / palladium(II) acetate; n-butylamine; Ph₃P / CuI / benzene / 20 °C

4.1: 96 percent / potassium carbonate / methanol / 2 h / 20 °C

With n-butyllithium; palladium diacetate; sodium hydride; potassium carbonate; N-butylamine; triphenylphosphine; copper(l) iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(00)00865-6

Reference yield:

: 130372-07-5
4-(tret-butyldiphenylsilyloxy)butan-1-ol

: 328382-15-6
(2R,3S)-2-[5-Benzyloxy-8-(tert-butyl-diphenyl-silanyloxy)-2-methylene-oct-3-ynyl]-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / potassium acetate; pyridinium chlorochromate / CH₂Cl₂ / 2 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.2: 92 percent / tetrahydrofuran / 0.25 h / 0 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 85 percent / dimethylformamide / 2 h / 20 °C

4.1: 89 percent / palladium(II) acetate; n-butylamine; Ph₃P / CuI / benzene / 20 °C

5.1: 96 percent / potassium carbonate / methanol / 2 h / 20 °C

With n-butyllithium; potassium acetate; palladium diacetate; sodium hydride; potassium carbonate; N-butylamine; triphenylphosphine; pyridinium chlorochromate; copper(l) iodide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(00)00865-6