1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

Base Information

Chemical Name:1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal
CAS No.:346577-66-0
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

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Chemical Property of 1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

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Technology Process of 1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

There total 8 articles about 1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 164987-79-5
1,5-Dibromopentan-3-one ethylene ketal

: 346577-65-9
1-benzyl-5-ethoxy-2-indolinone

: 346577-66-0
1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

Guidance literature:: 1-benzyl-5-ethoxy-2-indolinone; With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 0.25h;

1,5-Dibromopentan-3-one ethylene ketal; In 1,2-dimethoxyethane; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jo0004658

Reference yield:

: 15484-91-0
N-benzylidene-4-ethoxyaniline

: 346577-66-0
1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

Guidance literature:: Multi-step reaction with 5 steps

1.1: 23.31 g / NaBH₄ / methanol / 2 h / 20 °C

2.1: tetrahydrofuran / 5.5 h / Heating

2.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

3.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

4.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

5.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

5.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

With potassium hydroxide; sodium tetrahydroborate; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo0004658

Reference yield:

: 72753-31-2
N-benzyl-N-(4-ethoxyphenyl)amine

: 346577-66-0
1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 5.5 h / Heating

1.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

2.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

3.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

4.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

4.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

With potassium hydroxide; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo0004658