N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide
CAS No.:152169-46-5
Molecular Formula:C₁₉H₂₉F₂NO₃Si
Molecular Weight:385.526
Hs Code.:
DSSTox Substance ID:DTXSID901114556

Synonyms:SCHEMBL8782482;DTXSID901114556;152169-46-5;N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide

Suppliers and Price of N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:385.18847665
Heavy Atom Count:26
Complexity:492

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=CC(=C(C(=C1F)[Si](C)(C)C)F)OC2CCCCO2

Technology Process of N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide

There total 9 articles about N-[2,4-Difluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-(trimethylsilyl)phenyl]-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 152169-45-4
2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

: 152169-46-5
2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol

Guidance literature:: With n-butyllithium; chloro-trimethyl-silane; sodium chloride; diisopropylamine; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 367-27-1
2,4-difluorophenol

: 152169-46-5
2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 2 h / 10 - 20 °C

2: HNO₃, H₂SO₄ / 1 h / 10 - 20 °C

3: NaHCO₃, methanol / 16 h / Ambient temperature

4: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C

5: 91 percent / pyridine / 0.5 h / 0 °C

6: 86 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) LDA / 1.) THF, hexane, from -78 to -55 deg C, 10 min, 2.) THF, hexane, from -78 to -60 deg C, 1 h

With pyridine; methanol; sulfuric acid; (1S)-10-camphorsulfonic acid; hydrogen; nitric acid; sodium hydrogencarbonate; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1997-1379

Reference yield:

: 113512-57-5
2,4-difluoro-5-nitrophenol

: 152169-46-5
2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C

2: 91 percent / pyridine / 0.5 h / 0 °C

3: 86 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) LDA / 1.) THF, hexane, from -78 to -55 deg C, 10 min, 2.) THF, hexane, from -78 to -60 deg C, 1 h

With pyridine; (1S)-10-camphorsulfonic acid; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1997-1379