METHYL 4,4'-BIPHENYL-R-ALANATE

Base Information

• Chemical Name: METHYL 4,4'-BIPHENYL-R-ALANATE
• CAS No.: 169885-19-2
• Molecular Formula: C₁₆H₁₇NO₂*ClH
• Molecular Weight: 291.777
• Hs Code.: 2922499990
• Mol file: 169885-19-2.mol

Synonyms:[1,1'-Biphenyl]-4-propanoicacid, a-amino-, methyl ester, hydrochloride,(R)-; [1,1'-Biphenyl]-4-propanoic acid, a-amino-, methyl ester, hydrochloride, (aR)- (9CI)

Chemical Property of METHYL 4,4'-BIPHENYL-R-ALANATE

Chemical Property:

• Boiling Point: 390.2°Cat760mmHg
• Flash Point: 226°C
• PSA: 52.32000
• Density: 1.119g/cm³
• LogP: 3.09670

Purity/Quality:

98% ^*data from raw suppliers

METHYL 4,4'-BIPHENYL-R-ALANATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4,4'-BIPHENYL-R-ALANATE

There total 3 articles about METHYL 4,4'-BIPHENYL-R-ALANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (155760-02-4,170080-13-4) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With thionyl chloride; at 0 ℃; for 16h; Reflux;

DOI:10.1002/cmdc.201600218

Reference yield: 94.0%

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate (137255-86-8) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 3h; Ambient temperature;

DOI:10.1021/jo00027a066

Reference yield:

methanol (67-56-1) + N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine (119273-61-9,128779-47-5,147923-08-8) → (S)-2-amino-3-(biphenyl-4-yl)-propionic acid methyl ester hydrochloride (63024-30-6,169885-19-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

DOI:10.1002/psc.2414

upstream raw materials:

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate

methanol

(S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid

N-tert-butoxycarbonyl-p-phenyl-L-phenylalanine

Refernces

• 1、 Mollica, Adriano,Feliciani, Federica,Stefanucci, Azzurra,Costante, Roberto,Lucente, Gino,Pinnen, Francesco,Notaristefano, Daniela,Spisani, Susanna. "Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues". experimental part. p. 418 - 426. Retrieved 2012/08/28.
• 2、 -. "Phosphono/biaryl substituted dipetide derivatives". . . Retrieved 2008/06/13.