dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate

Base Information

• Chemical Name: dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate
• CAS No.: 172275-56-8
• Molecular Formula: C₂₅H₂₄O₅
• Molecular Weight: 404.463
• Mol file: 172275-56-8.mol

Synonyms:dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate

Chemical Property of dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate

There total 1 articles about dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

benzyl bromide (100-39-0) + dibenzyl (2S)-2-hydroxybutanedioate (85719-40-0) → dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate (172275-56-8)

Guidance literature:

dibenzyl (2S)-2-hydroxybutanedioate; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm701049p

Reference yield: 56.0%

dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate (172275-56-8) → (2S,3S)-3-benzyl-1,2,4-butanetriol (88481-71-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm701049p

Reference yield: 50.0%

dibenzyl (2S,3R)-2-benzyl-3-hydroxybutanedioate (172275-56-8) → dibenzyl 2-benzylidenesuccinate (1365265-70-8) + (E)-dibenzyl 2-benzylfumarate (1365265-51-5)

Guidance literature:

With phthalimide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.tetasy.2012.01.004

upstream raw materials:

benzyl bromide

dibenzyl (2S)-2-hydroxybutanedioate

Downstream raw materials:

(2S,3S)-3-benzyl-1,2,4-butanetriol

C₂₅H₂₄O₆

dibenzyl 2-benzylidenesuccinate

(E)-dibenzyl 2-benzylfumarate