2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether

Base Information

• Chemical Name: 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether
• CAS No.: 5920-85-4
• Molecular Formula: C₂₀H₃₈OSi₂
• Molecular Weight: 350.692
• Mol file: 5920-85-4.mol

Synonyms:2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether

Chemical Property of 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether

There total 3 articles about 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloro-trimethyl-silane (75-77-4) + 2-bromo-4,6-di-tert-butylphenyl trimethylsilyl ether (5920-84-3) → 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether (5920-85-4)

Guidance literature:

2-bromo-4,6-di-tert-butylphenyl trimethylsilyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1248/cpb.c18-00578

Reference yield:

2-bromo-4,6-di-tert-butylphenol (20834-61-1) → 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether (5920-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1248/cpb.c18-00578

Reference yield:

→ 2-(trimethylsilyl)-4,6-di-tert-butylphenyl trimethylsilyl ether (5920-85-4)

Guidance literature:

<2-Brom-4,6-di-tert.-butyl-phenoxy>-trimethyl-silan (I), Natrium, Chlor-trimethylsilan, sd. Toluol;

upstream raw materials:

chloro-trimethyl-silane

2-bromo-4,6-di-tert-butylphenyl trimethylsilyl ether

2-bromo-4,6-di-tert-butylphenol

Downstream raw materials:

1,3-di-tert-butyl-5-fluorobenzene