2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

Base Information

Chemical Name:2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester
CAS No.:400648-61-5
Molecular Formula:C₂₂H₂₈N₂O₅
Molecular Weight:400.475
Hs Code.:

Synonyms:2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

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Chemical Property of 2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

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Technology Process of 2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

There total 3 articles about 2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-84-2
isobutyraldehyde

: 400648-60-4
ethyl 2-(3-amino-4-methoxyphenyl)-3-(4-nitrophenyl)propanoate

: 400648-61-5
2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol;
DOI:10.1016/j.bmcl.2004.09.089

Reference yield:

: 824402-51-9
(4-Methoxy-3-{[1-phenyl-meth-(E)-ylidene]-amino}-phenyl)-acetic acid ethyl ester

: 400648-61-5
2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: aq. HCl

3.1: NaBH(OAc)3 / methanol

With hydrogenchloride; sodium tris(acetoxy)borohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.09.089

Reference yield:

: 400648-59-1
2-(4-Methoxy-3-{[1-phenyl-meth-(E)-ylidene]-amino}-phenyl)-3-(4-nitro-phenyl)-propionic acid ethyl ester

: 400648-61-5
2-[(3-isobutylamino)-4-methoxy phenyl]-3-(4-nitrophenyl)propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl

2: NaBH(OAc)3 / methanol

With hydrogenchloride; sodium tris(acetoxy)borohydride; In methanol;
DOI:10.1016/j.bmcl.2004.09.089