C₂₂H₂₇N₅O₄

Base Information

• Chemical Name: C₂₂H₂₇N₅O₄
• CAS No.: 1246520-69-3
• Molecular Formula: C₂₂H₂₇N₅O₄
• Molecular Weight: 425.487
• Mol file: 1246520-69-3.mol

Synonyms:C₂₂H₂₇N₅O₄

Chemical Property of C₂₂H₂₇N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₇N₅O₄

There total 10 articles about C₂₂H₂₇N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di(succinimido) carbonate (74124-79-1) + C19H22N4O3 (1246521-40-3) + dimethyl amine (124-40-3) → C22H27N5O4 (1246520-69-3)

Guidance literature:

di(succinimido) carbonate; C₁₉H₂₂N₄O₃; With N,N'-dimethylaminopyridine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 23h;

dimethyl amine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 48h;

Reference yield:

3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → C22H27N5O4 (1246520-69-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: trifluoroacetic acid / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

6.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C

6.2: 18 h / 60 °C

7.1: N,N'-dimethylaminopyridine / acetonitrile; tetrahydrofuran / 23 h / 20 °C

7.2: 48 h / 20 °C

With N-chloro-succinimide; water; hydrogen; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → C22H27N5O4 (1246520-69-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: Cooling with ice

6.1: trifluoroacetic acid / 16 h / Reflux

7.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

8.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C

8.2: 18 h / 60 °C

9.1: N,N'-dimethylaminopyridine / acetonitrile; tetrahydrofuran / 23 h / 20 °C

9.2: 48 h / 20 °C

With N-chloro-succinimide; water; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

di(succinimido) carbonate

C₁₉H₂₂N₄O₃

dimethyl amine

2-chloro-3-carbaldehydepyridine