2-cyclohexyl-3-phenyloxaziridine

Base Information

• Chemical Name: 2-cyclohexyl-3-phenyloxaziridine
• CAS No.: 21711-00-2
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.284
• Mol file: 21711-00-2.mol

Synonyms:NSC 345387

Chemical Property of 2-cyclohexyl-3-phenyloxaziridine

Chemical Property:

• Vapor Pressure: 0.00234mmHg at 25°C
• Boiling Point: 288.4°Cat760mmHg
• Flash Point: 84.2°C
• Density: 1.131g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyclohexyl-3-phenyloxaziridine

There total 5 articles about 2-cyclohexyl-3-phenyloxaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-phenyl(methylidene)cyclohexanamine (2211-66-7) → 2-cyclohexyl-3-phenyl-1,2-oxaziridine (21711-00-2,75768-08-0,75780-72-2)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; urea hydrogen peroxide adduct; at 45 ℃; for 15h; Green chemistry;

DOI:10.1021/acs.joc.0c01579

Reference yield: 98.0%

cyclohexylamine (108-91-8,157973-60-9) + benzaldehyde (100-52-7) → 2-cyclohexyl-3-phenyl-1,2-oxaziridine (21711-00-2,75768-08-0,75780-72-2)

Guidance literature:

With dihydrogen peroxide; carbonic acid dimethyl ester; In water; at 20 ℃; for 15h; Green chemistry;

DOI:10.1039/c6gc03589b

Reference yield: 70.0%

(E)-N-cyclohexyl-1-phenylmethanimine (27845-53-0) → 2-cyclohexyl-3-phenyl-1,2-oxaziridine (21711-00-2,75768-08-0,75780-72-2)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1055/s-2005-865219

upstream raw materials:

N-phenyl(methylidene)cyclohexanamine

(E)-N-cyclohexyl-1-phenylmethanimine

cyclohexylamine

benzaldehyde

Downstream raw materials:

N-benzoylcyclohexylamine

2-benzhydrylidene-3-cyclohexyl-5,5-diphenyl-oxazolidin-4-one

5-cyclohexylimino-2,4-diphenyl-[1,2,4]thiadiazolidine-3-thione

Refernces

• 1、 Llopis, Natalia,Gisbert, Patricia,Baeza, Alejandro. "Direct Synthesis of N,N-Disubstituted Formamides by Oxidation of Imines Using an HFIP/UHP System". . p. 11072 - 11079. Retrieved 2020/10/12.
• 2、 Ghosh, Asit,Mandal, Subhajit,Chattaraj, Pratim Kumar,Banerjee, Prabal. "Ring Expansion of Donor-Acceptor Cyclopropane via Substituent Controlled Selective N-Transfer of Oxaziridine: Synthetic and Mechanistic Insights". supporting information. p. 4940 - 4943. Retrieved 2016/10/18.