(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

Base Information

Chemical Name:(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene
CAS No.:237736-53-7
Molecular Formula:C₂₃H₃₉IO₅Si
Molecular Weight:550.55
Hs Code.:

Synonyms:(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

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Technology Process of (E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

There total 5 articles about (E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 263887-37-2
2-(1-Ethoxy-ethoxy)-4-[(E)-3-(1-ethoxy-ethoxy)-propenyl]-6-iodo-phenol

: 237736-53-7
(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.3987/com-99-s63

Reference yield:

: 172515-98-9
(E)-3-(3-Iodo-4-methanesulfonyloxy-5-methoxy-phenyl)-acrylic acid ethyl ester

: 237736-53-7
(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / BBr₃ / CHCl₃ / 52 h / 0 °C

2: 99 percent / DIBALH / tetrahydrofuran; toluene / 4 h / -78 °C

3: 74 percent / PPTS / tetrahydrofuran / 13 h / 0 °C

4: 1N aq. NaOH / tetrahydrofuran; methanol / 3 h / 50 °C

5: imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; sodium hydroxide; pyridinium p-toluenesulfonate; boron tribromide; diisobutylaluminium hydride; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Reduction / 3: Etherification / 4: Hydrolysis / 5: Etherification;
DOI:10.3987/com-99-s63

Reference yield:

: 237736-54-8
(E)-3-(5-hydroxy-3-iodo-4-mesyloxyphenyl)-2-propen-1-ol

: 237736-53-7
(E)-3-(1-ethoxyethoxy)-1-[4-tert-butyldimethylsiloxy-5-(1-ethoxyethoxy)-3-iodophenyl]-1-propene

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / PPTS / tetrahydrofuran / 13 h / 0 °C

2: 1N aq. NaOH / tetrahydrofuran; methanol / 3 h / 50 °C

3: imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; sodium hydroxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Etherification / 2: Hydrolysis / 3: Etherification;
DOI:10.3987/com-99-s63