Bis[4-(methylthio)phenyl] ether

Base Information

• Chemical Name: Bis[4-(methylthio)phenyl] ether
• CAS No.: 35370-99-1
• Molecular Formula: C₁₄H₁₄OS₂
• Molecular Weight: 262.397
• DSSTox Substance ID: DTXSID401289083
• Nikkaji Number: J1.161.047A
• Mol file: 35370-99-1.mol

Synonyms:SCHEMBL2774995;Bis[4-(methylthio)phenyl] ether;DTXSID401289083;Benzene, 1,1'-oxybis[4-(methylthio)-;1-(methylsulfanyl)-4-[4-(methylsulfanyl)phenoxy]benzene;35370-99-1

Chemical Property of Bis[4-(methylthio)phenyl] ether

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 262.04860741
• Heavy Atom Count: 17
• Complexity: 184

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CSC1=CC=C(C=C1)OC2=CC=C(C=C2)SC

Technology Process of Bis[4-(methylthio)phenyl] ether

There total 5 articles about Bis[4-(methylthio)phenyl] ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

diphenylether (101-84-8) + Dimethyldisulphide (624-92-0) → bis-(4-methylsulfanyl-phenyl)-ether (35370-99-1) + methyl (4-phenyloxy)phenyl sulfide (21134-14-5)

Guidance literature:

With tert-butylammonium hexafluorophosphate(V); platinum; In liquid sulphur dioxide; at -15 ℃; for 3h; Electrochemical reaction;

DOI:10.1016/S0040-4039(99)01311-8

Reference yield:

4,4'-oxybis(benzenesulfonyl chloride) (121-63-1) → bis-(4-methylsulfanyl-phenyl)-ether (35370-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂; HCl; glacial acetic acid

2: aqueous NaOH

With hydrogenchloride; sodium hydroxide; acetic acid; tin(ll) chloride;

DOI:10.1021/ja01292a015

Reference yield:

4-(4-sulfanylphenoxy)thiophenol (17527-79-6) + dimethyl sulfate (77-78-1) → bis-(4-methylsulfanyl-phenyl)-ether (35370-99-1)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01292a015

upstream raw materials:

4-(4-sulfanylphenoxy)thiophenol

dimethyl sulfate

diphenylether

Dimethyldisulphide