N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Base Information

Chemical Name:N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine
CAS No.:223409-35-6
Molecular Formula:C₂₅H₃₅N₅O₄Si
Molecular Weight:497.669
Hs Code.:

N<sup>6</sup>-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Synonyms:N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Suppliers and Price of N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Chemical Property:

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Technology Process of N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

There total 7 articles about N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 223409-31-2
N⁶-benzoyl-9-(4-ethoxycarbonyl-3-hydroxobutyl)adenine

: 223409-35-6
N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 70 ℃; for 72h; sealed tube;
DOI:10.1002/(SICI)1099-0690(199904)1999:4<931::AID-EJOC931>3.0.CO;2-R

Reference yield:

: 223409-15-2
9-(2-tert-butoxycarbonylethyl)adenine

: 223409-35-6
N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / acetonitrile; pyridine / 12 h / Heating

2: 61 percent / HCl / ethyl acetate / 24 h / Ambient temperature

3: 1.) CDI, 2.) Mg(OEt)2 / 1.) THF, rt, 6 h, 2.) THF, 20 h

4: 62 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h

5: 69 percent / imidazole / dimethylformamide / 72 h / 70 °C / sealed tube

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; magnesium ethylate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; pyridine; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199904)1999:4<931::AID-EJOC931>3.0.CO;2-R

Reference yield:

: 98-88-4
benzoyl chloride

: 223409-35-6
N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / acetonitrile; pyridine / 12 h / Heating

2: 61 percent / HCl / ethyl acetate / 24 h / Ambient temperature

3: 1.) CDI, 2.) Mg(OEt)2 / 1.) THF, rt, 6 h, 2.) THF, 20 h

4: 62 percent / NaBH₄ / ethanol; tetrahydrofuran / 2 h

5: 69 percent / imidazole / dimethylformamide / 72 h / 70 °C / sealed tube

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; magnesium ethylate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; pyridine; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/(SICI)1099-0690(199904)1999:4<931::AID-EJOC931>3.0.CO;2-R