Technology Process of 2-bromo-3,6-dimethoxyaniline
There total 2 articles about 2-bromo-3,6-dimethoxyaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iron(III) chloride; pyrographite; hydrazine hydrate;
In
methanol;
for 12h;
Heating;
DOI:10.1021/jo00383a032
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) sodium nitrite, conc. H2SO4, 2.) copper(I)bromide, hydrogen bromide / 1.) methanol, water, 0 deg C, 30 min, 2.) methanol, water, reflux, 1 h
2: 100 percent / activated carbon, ferric chloride hexahydrate, hydrazine hydrate / methanol / 12 h / Heating
With
sulfuric acid; hydrogen bromide; iron(III) chloride; pyrographite; hydrazine hydrate; copper(I) bromide; sodium nitrite;
In
methanol;
DOI:10.1021/jo00383a032
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) sodium nitrite, conc. HCl, 2.) potassium iodide / 1.) water, 0 deg C, 20 min, 2.) water, RT, overnight
2: 78 percent / pyridine / 12 h / Heating
3: 1.) n-butyllithium / 1.) hexane, ether, -78 deg C, 20 min, 2.) hexane, ether, from -78 deg C to 0 deg C, 2 h
4: 75 percent / pyridinium chlorochromate, 3-A molecular sieves / CH2Cl2 / 4 h / Ambient temperature
With
pyridine; hydrogenchloride; n-butyllithium; 3 A molecular sieve; pyridinium chlorochromate; potassium iodide; sodium nitrite;
In
dichloromethane;
DOI:10.1021/jo00383a032
