6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid

Base Information

• Chemical Name: 6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid
• CAS No.: 1072881-33-4
• Molecular Formula: C₂₂H₂₃NO₅
• Molecular Weight: 381.428
• Mol file: 1072881-33-4.mol

Synonyms:6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid

Chemical Property of 6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid

There total 1 articles about 6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-methoxylindole (1006-94-6) + (E)-6-[4-methoxyphenyl]-4-oxohex-5-enoic acid (121365-32-0) → 6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid (1072881-33-4)

Guidance literature:

With iodine; In ethanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2008.07.084

Reference yield: 84.0%

6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid (1072881-33-4) + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → methyl (2S)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]-3-phenyl-propanoate (1072881-39-0)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2008.07.084

Reference yield: 81.0%

6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanoic acid (1072881-33-4) + L-tyrosine ethyl ester (949-67-7) → ethyl (2S)-3-(4-hydroxyphenyl)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]propanoate (1072881-37-8)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2008.07.084

upstream raw materials:

5-methoxylindole

(E)-6-[4-methoxyphenyl]-4-oxohex-5-enoic acid

Downstream raw materials:

methyl (2S)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]-3-phenyl-propanoate

ethyl (2S)-3-(4-hydroxyphenyl)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]propanoate

methyl (2S)-3-(1H-imidazol-4-yl)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]propanoate

methyl (2S)-3-(1H-indol-3-yl)-2-[6-(5-methoxy-1H-indol-3-yl)-6-(4-methoxyphenyl)-4-oxohexanamido]propanoate