Technology Process of 1-(4'-decyl-2'-hydroxyphenyl)-2-methoxy-3-(2'',3'',5'',6''-tetramethoxyphenyl)propane-1,3-dione
There total 6 articles about 1-(4'-decyl-2'-hydroxyphenyl)-2-methoxy-3-(2'',3'',5'',6''-tetramethoxyphenyl)propane-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2'-hydroxy-4'-decyl-2-methoxy-acetophenone;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
2,3,5,6-Tetramethoxy-benzoylchlorid;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1.08333h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
Inert atmosphere;
DOI:10.1139/v11-087
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / Inert atmosphere
1.2: Inert atmosphere
2.1: sodium chlorite; aminosulfonic acid / tetrahydrofuran; water; dimethyl sulfoxide / Inert atmosphere
3.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
4.2: 1.08 h / -78 - 20 °C / Inert atmosphere
4.3: 20 °C / Inert atmosphere
With
sodium chlorite; n-butyllithium; thionyl chloride; aminosulfonic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1139/v11-087
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: water; potassium hydroxide / tetrahydrofuran / Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; water / Inert atmosphere
3.1: n-butyllithium / Inert atmosphere
3.2: Inert atmosphere
4.1: sodium chlorite; aminosulfonic acid / tetrahydrofuran; water; dimethyl sulfoxide / Inert atmosphere
5.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 1.08 h / -78 - 20 °C / Inert atmosphere
6.3: 20 °C / Inert atmosphere
With
sodium chlorite; n-butyllithium; thionyl chloride; aminosulfonic acid; water; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1139/v11-087
