7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Base Information

Chemical Name:7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester
CAS No.:247132-47-4
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

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Chemical Property of 7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

There total 10 articles about 7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247132-46-3
benzyl 7-(1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxylate

: 144-55-8
sodium hydrogencarbonate

: 247132-47-4
7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform;

Reference yield:

: 247132-46-3
benzyl 7-(1-tert-butoxycarbonyl-4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinolin-2-carboxylate

: 247132-47-4
7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 1h;
DOI:10.1021/jm058160e

Reference yield:

: 39989-39-4
7-methoxyisoquinoline

: 247132-47-4
7-(4-ethoxycarbonylpiperidin-4-ylmethoxy)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂; AcOH / PtO₂ / 3 h / 2280 Torr

2.1: aq. HBr / 3 h / Heating

3.1: aq. NaOH / tetrahydrofuran / 20 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 89 percent / dimethylformamide / 12 h / 20 °C

5.1: SO₂Cl₂ / CH₂Cl₂ / 1 h / 0 °C

6.1: LDA / tetrahydrofuran / 20 h / 20 °C

6.2: 48 percent / tetrahydrofuran / -70 - 20 °C

7.1: TFA / CHCl₃ / 1 h / 20 °C

With sodium hydroxide; sulfuryl dichloride; hydrogen bromide; hydrogen; sodium hydride; acetic acid; trifluoroacetic acid; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm058160e