(3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine

Base Information

• Chemical Name: (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine
• CAS No.: 153257-53-5
• Molecular Formula: C₁₉H₂₂FNO₃S
• Molecular Weight: 363.453

Synonyms:(3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine

Chemical Property of (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine

Chemical Property:

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Technology Process of (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine

There total 2 articles about (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzenesulfonyl chloride (98-09-9) + (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine (105812-81-5) → (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine (153257-53-5)

Guidance literature:

With N,N-dimethyl-ethanamine; In toluene; at 0 - 10 ℃; for 1.83333h;

Reference yield:

N,N-dimethyl-ethanamine (598-56-1) + benzenesulfonyl chloride (98-09-9) + (3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine (105812-81-5) → 4-(4'-fluorophenyl)-1-methyl-3-(3',4'-methylenedioxy-phenoxymethyl) piperidine + (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine (153257-53-5)

Guidance literature:

In dichloromethane; water;

Reference yield:

benzo[d][1,3]dioxol-(2,2-d2)-5-ol (923932-05-2) + (3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-phenylsulphonyloxymethylpiperidine (153257-53-5) → (3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine (936838-88-9)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 71 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

N,N-dimethyl-ethanamine

benzenesulfonyl chloride

(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

Downstream raw materials:

(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

(3S,4R)-3-((benzo[d][1,3]dioxol-(2,2-d2)-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride

(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine

(3S,4R)-4-phenyl 3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

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