2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide

Base Information

• Chemical Name: 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide
• CAS No.: 1373489-36-1
• Molecular Formula: C₁₄H₁₁Cl₂FN₂O
• Molecular Weight: 313.159

Synonyms:2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide

Chemical Property of 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide

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Technology Process of 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide

There total 1 articles about 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(3-fluorophenyl)methanamine (100-82-3) + 2,6-dichloro-4-methyl-nicotinic acid (62774-90-7) → 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide (1373489-36-1)

Guidance literature:

With triethylamine; HATU; In tetrahydrofuran; at 70 ℃;

Reference yield: 76.0%

2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide (1373489-36-1) + ethanethiol (75-08-1) → 6-chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-pyridine-3-carboxylic acid amide (1373489-37-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 54.0%

methanol (67-56-1) + 2,6-dichloro-N-(3-fluorobenzyl)-4-methyl-pyridine-3-carboxylic acid amide (1373489-36-1) → 6-chloro-N-[(3-fluorophenyl)-methyl]-2-methoxy-4-methyl-pyridine-3-carboxylic acid amide (1373489-47-4)

Guidance literature:

With sodium hydride; In mineral oil; at 70 ℃; for 24h;

upstream raw materials:

(3-fluorophenyl)methanamine

2,6-dichloro-4-methyl-nicotinic acid

Downstream raw materials:

2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-pyridine-3-carboxylic acid amide

6-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-2-morpholin-4-yl-pyridine-3-carboxylic acid amide

2-chloro-N-(3-fluorobenzyl)-4-methyl-6-thiomorpholino-pyridine-3-carboxylic acid amide

6-chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-pyridine-3-carboxylic acid amide

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