4-[2-(2-AMino-phenyl)-thiazolo[5,4-b]pyridin-6-ylMethoxy]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[2-(2-AMino-phenyl)-thiazolo[5,4-b]pyridin-6-ylMethoxy]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1344033-89-1
• Molecular Formula: C₂₃H₂₈N₄O₃S
• Molecular Weight: 440.566
• Mol file: 1344033-89-1.mol

Synonyms:tert-butyl 4-((2-(2-aminophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

Chemical Property of 4-[2-(2-AMino-phenyl)-thiazolo[5,4-b]pyridin-6-ylMethoxy]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(2-AMino-phenyl)-thiazolo[5,4-b]pyridin-6-ylMethoxy]-piperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[2-(2-AMino-phenyl)-thiazolo[5,4-b]pyridin-6-ylMethoxy]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 4-((2-(2-nitrophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-88-0) → tert-butyl 4-((2-(2-aminophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-89-1)

Guidance literature:

With iron; acetic acid; In tetrahydrofuran; water; at 50 ℃;

DOI:10.1016/bs.mie.2016.01.012

Reference yield:

6-(bromomethyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine (925438-37-5) → tert-butyl 4-((2-(2-aminophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 15 h / 20 °C

2: iron; ammonium chloride / water; isopropyl alcohol / 1.75 h / Reflux

With tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; sodium hydroxide; In water; isopropyl alcohol; toluene;

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((2-(2-aminophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate (1344033-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 15 h / 20 °C

2: iron; ammonium chloride / water; isopropyl alcohol / 1.75 h / Reflux

With tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; sodium hydroxide; In water; isopropyl alcohol; toluene;

upstream raw materials:

tert-butyl 4-((2-(2-nitrophenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

6-(bromomethyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine

t-butyl 4-hydroxy piperidine-1-carboxylate

N-(2-chloro-5-methylpyridin-3-yl)-2-nitrobenzamide

Downstream raw materials:

tert-butyl 4-((2-(2-(2-butyl-6-chloropyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate

2-butyl-6-(piperidin-4-ylamino)-N-(2-(6-((piperidin-4-yloxy)methyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

tert-butyl 4-((2-(2-(6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-butylpyrimidine-4-carboxamido)phenyl)thiazolo[5,4-b]pyridin-6-yl)methoxy)piperidine-1-carboxylate