methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

Base Information

Chemical Name:methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate
CAS No.:1215106-79-8
Molecular Formula:C₂₂H₁₆FNO₄
Molecular Weight:377.372
Hs Code.:

Synonyms:methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

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Chemical Property of methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

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Technology Process of methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

There total 6 articles about methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 201230-82-2
carbon monoxide

: 1215106-78-7
6-(benzyloxy)-4-((4-fluorophenyl)ethynyl)pyridin-3-ol

: 1215106-79-8
methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

Guidance literature:: With copper(II) choride dihydrate; sodium acetate; potassium carbonate; palladium dichloride; In methanol; at 20 ℃; under 15514.9 Torr;

Reference yield: 100.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1215106-78-7
6-(benzyloxy)-4-((4-fluorophenyl)ethynyl)pyridin-3-ol

: 1215106-79-8
methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

Guidance literature:: With copper(II) choride dihydrate; sodium acetate; potassium carbonate; palladium dichloride; at 20 ℃; under 15514.9 Torr; Parr bomb;

Reference yield:

: 725256-57-5
6-benzyloxy-3-hydroxypyridine

: 1215106-79-8
methyl 5-(benzyloxy)-2-(4-fluorophenyl)furo[2,3-c]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C

1.2: 2 h / 20 °C

2.1: tert.-butyl lithium / tetrahydrofuran / -78 °C

2.2: -78 °C

3.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 80 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 5 h / 20 °C

5.1: potassium carbonate; sodium acetate; copper(II) choride dihydrate / palladium dichloride / 20 °C / 15514.9 Torr / Parr bomb

With copper(l) iodide; copper(II) choride dihydrate; tert.-butyl lithium; sodium acetate; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; trans-bis(triphenylphosphine)palladium dichloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;