methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate

Base Information

• Chemical Name: methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate
• CAS No.: 225090-48-2
• Molecular Formula: C₁₅H₂₀O₈
• Molecular Weight: 328.319
• Mol file: 225090-48-2.mol

Synonyms:methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate

Chemical Property of methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate

There total 3 articles about methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-(bromo-methoxycarbonyl-methyl)-3,5,6-trimethoxy-benzoic acid methyl ester (259752-90-4) → methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate (225090-48-2)

Guidance literature:

With sodium methylate; In dichloromethane; at -78 - 20 ℃; Yield given;

DOI:10.1002/(SICI)1521-3773(19990301)38:5<683::AID-ANIE683>3.0.CO;2-0

Reference yield:

methyl 2,3,5-trimethoxy-6-(methoxycarbonylmethyl)benzoate (225090-44-8) → methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate (225090-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 °C

1.2: NBS / tetrahydrofuran / 1.5 h / -78 °C

2.1: 0.66 g / methanol; CH₂Cl₂ / 16 h / -78 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja0035699

Reference yield:

sodium methylate (124-41-4) + 2-(bromo-methoxycarbonyl-methyl)-3,5,6-trimethoxy-benzoic acid methyl ester (259752-90-4) → methyl 2-methoxy-2-<3,4,6-trimethoxy-2-(methoxycarbonyl)phenyl>acetate (225090-48-2)

Guidance literature:

In methanol; dichloromethane; at -78 - 20 ℃; for 16h;

DOI:10.1021/ja0035699

upstream raw materials:

methanol

2-(bromo-methoxycarbonyl-methyl)-3,5,6-trimethoxy-benzoic acid methyl ester

sodium methylate

methyl 2,3,5-trimethoxy-6-(methoxycarbonylmethyl)benzoate

Downstream raw materials:

fredericamycin A

2-(carboxy-methoxy-methyl)-3,5,6-trimethoxy-benzoic acid