2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

Base Information

Chemical Name:2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene
CAS No.:502481-63-2
Molecular Formula:C₁₉H₂₇N₃O₇
Molecular Weight:409.439
Hs Code.:

Synonyms:2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

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Chemical Property of 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

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Technology Process of 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

There total 8 articles about 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 502481-63-2
2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / (MeO)3B; BF₃*OEt₂; BH₃*pyridine / 1,2-dichloro-ethane / 4 h / 20 °C

2: K₂CO₃ / dimethylformamide / 50 °C

3: Et₃N / CH₂Cl₂ / 0 °C

4: dimethylformamide / 20 °C

5: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

6: ethyl acetate / 20 °C

With borane pyridine; Trimethyl borate; boron trifluoride diethyl etherate; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 61161-83-9
5-(hydroxymethyl)-2-nitrophenol

: 502481-63-2
2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 50 °C

2: Et₃N / CH₂Cl₂ / 0 °C

3: dimethylformamide / 20 °C

4: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

5: ethyl acetate / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 135206-87-0
(2R)-1-morpholin-4-yl-1-oxopropane-2-ol

: 502481-63-2
2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 0 - 50 °C

1.2: tetrahydrofuran / 0 - 5 °C

2.1: K₂CO₃ / dimethylformamide / 50 °C

3.1: Et₃N / CH₂Cl₂ / 0 °C

4.1: dimethylformamide / 20 °C

5.1: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

6.1: ethyl acetate / 20 °C

With sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l