methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

Base Information

Chemical Name:methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate
CAS No.:913078-86-1
Molecular Formula:C₁₈H₁₄F₃NO₅
Molecular Weight:381.308
Hs Code.:

Synonyms:methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

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Chemical Property of methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

Chemical Property:

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Technology Process of methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

There total 6 articles about methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 913078-71-4
(2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylic acid

: 74-88-4
methyl iodide

: 913078-86-1
methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 1.5h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 907587-46-6
methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 913078-86-1
methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / lithium borohydride / diethyl ether; methanol / Heating

2: 81 percent / dimethylsulfoxide; sulfur trioxide pyridine complex; diisopropylethylamine / ethyl acetate / 0.5 h

3: 90 percent / piperidine; pyridine / 0.5 h / 100 °C

4: 100 percent / potassium carbonate / dimethylformamide / 1.5 h / 65 °C

With piperidine; pyridine; lithium borohydride; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 913078-70-3
4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}benzaldehyde

: 913078-86-1
methyl (2E)-3-(4-{[2-nitro-5-(trifluoromethyl)phenoxy]methyl}phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / piperidine; pyridine / 0.5 h / 100 °C

2: 100 percent / potassium carbonate / dimethylformamide / 1.5 h / 65 °C

With piperidine; pyridine; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067