(R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid

Base Information

• Chemical Name: (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid
• CAS No.: 146406-31-7
• Molecular Formula: C₂₃H₂₂NO₄P
• Molecular Weight: 407.406

Synonyms:(R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid

Chemical Property of (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid

Chemical Property:

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Technology Process of (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid

There total 1 articles about (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (R,S)-((1-amino)-2-phenylethyl) phosphinic acid (80744-66-7) → (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid (146406-31-7)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 6h;

DOI:10.1016/S0040-4020(01)00221-6

Reference yield: 75.0%

(R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid (146406-31-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl α-(9-fluorenylmethoxycarbonylamino)benzylphosphinate (241160-98-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1055/s-1992-26344

Reference yield:

chloro-trimethyl-silane (75-77-4) + (R,S)-(1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)phosphinic acid (146406-31-7) → C15H11O2NHCHCH2C6H5POO(Si(CH3)3)2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(01)00221-6

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(R,S)-((1-amino)-2-phenylethyl) phosphinic acid

Downstream raw materials:

benzyl α-(9-fluorenylmethoxycarbonylamino)benzylphosphinate

(R,R,S,S)-2-methyl-3-((1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)-hydroxyphosphinyl) propanoic acid, benzyl ester

(R,S)-3-((1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)-hydroxyphosphinyl) propanoic acid, benzyl ester

(R,R,S,S)-2-isobutyl-3-((1-(N-(9-fluorenylmethoxycarbonyl)amino)-2-phenylethyl)-hydroxyphosphinyl) propanoic acid, benzyl ester

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