4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol

Base Information

• Chemical Name: 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol
• CAS No.: 96372-25-7
• Molecular Formula: C₂₉H₂₉N₅O₂
• Molecular Weight: 479.582
• Mol file: 96372-25-7.mol

Synonyms:4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol

Chemical Property of 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol

There total 2 articles about 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-dimethylamino-benzaldehyde (100-10-7) + edaravone (89-25-8) → 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol (96372-25-7)

Guidance literature:

With Fe₃O₄ nanomagnetic core-shell SiO₂ supported (CH₂)₃-thiourea dioxide-SO₃H/HCl; In neat (no solvent); at 90 ℃; for 0.75h;

DOI:10.1002/aoc.3633

Reference yield: 89.0%

ethyl acetoacetate (141-97-9) + phenylhydrazine (100-63-0) + 4-dimethylamino-benzaldehyde (100-10-7) → 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol (96372-25-7)

Guidance literature:

With sulfonated melamine-functionalized Fe₃O₄/SiO₂/Si-(CH₂)₃/melamine nanoparticles; In neat (no solvent); at 110 ℃; for 0.166667h; Catalytic behavior;

DOI:10.1007/s13738-021-02420-8

Reference yield: 60.0%

4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol (96372-25-7) → 4-(4-(dimethylamino)benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (25111-96-0)

Guidance literature:

With sodium bromide; In methanol; at 20 ℃; Electrolysis;

DOI:10.3390/molecules26164960

upstream raw materials:

4-dimethylamino-benzaldehyde

edaravone

ethyl acetoacetate

phenylhydrazine

Downstream raw materials:

4-(4-(dimethylamino)benzylidene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

Refernces

• 1、 Barreiro-Costa, Olalla,Morales-Noboa, Gabriela,Rojas-Silva, Patricio,Lara-Barba, Eliana,Santamaría-Aguirre, Javier,Bailón-Moscoso, Natalia,Romero-Benavides, Juan Carlos,Herrera, Ana,Cueva, Cristina,Ron-Garrido, Lenin,Poveda, Ana,Heredia-Moya, Jorge. "Synthesis and evaluation of biological activities of bis(Spiropyrazolone)cyclopropanes: A potential application against Leishmaniasis". . . Retrieved 2021/08/30.
• 2、 Zolfigol, Mohammad Ali,Navazeni, Mahdiyeh,Yarie, Meysam,Ayazi-Nasrabadi, Roya. "Application of a biological-based nanomagnetic catalyst in the synthesis of bis-pyrazols and pyrano[3,2-c]pyrazoles". . . Retrieved 2017/05/22.