25111-96-0

Basic information

• Product Name: 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
• Synonyms: 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one;4-(4-DIMETHYLAMINOBENZYLIDENE-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;4-[4-(Dimethylamino)benzylidene]-1-phenyl-3-methyl-1H-pyrazole-5(4H)-one;Einecs 246-627-5
• CAS NO: 25111-96-0
• Molecular Formula: C19H19N3O
• Molecular Weight: 305.37366
• EINECS: 246-627-5
• Mol File: 25111-96-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 197-198 °C
• Boiling Point: 467.8°Cat760mmHg
• Flash Point: 236.7°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 6.31E-09mmHg at 25°C
• Refractive Index: 1.6
• PKA: 4.24±0.24(Predicted)
• CAS DataBase Reference: 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one(25111-96-0)
• EPA Substance Registry System: 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one(25111-96-0)

Safety Data

• Hazardous Substances Data: 25111-96-0(Hazardous Substances Data)

Usage

Description

4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one is a complex chemical compound belonging to the pyrazolone family, known for its diverse pharmacological properties. This specific compound features a dimethylamino group, a phenyl group, and a methyl group, among other functional groups, making it a promising candidate for drug development and research due to its reported biological activities.

Uses

Used in Pharmaceutical Research:
4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one is used as a drug candidate in pharmaceutical research for its potential anti-inflammatory and analgesic properties. Its unique structure and functional groups contribute to its biological activities, making it an interesting target for further study and potential development into therapeutic agents.
Used in Chemical Synthesis:
In the chemical synthesis industry, 4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one may be used as an intermediate or a building block in the synthesis of more complex molecules with specific applications in various fields, including medicine, agriculture, and materials science.
Used in Academic Research:
4-[[4-(dimethylamino)phenyl]methylene]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one is utilized in academic research settings to explore its chemical properties, reactivity, and potential interactions with biological systems. This research can lead to a better understanding of the compound's behavior and its possible applications in various scientific disciplines.

InChI:InChI=1/C19H19N3O/c1-14-18(13-15-9-11-16(12-10-15)21(2)3)19(23)22(20-14)17-7-5-4-6-8-17/h4-13H,1-3H3/b18-13+

Upstream product

• 96372-25-7 4-((4-(dimethylamino)phenyl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol 
• 100-63-0 phenylhydrazine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 89-25-8 edaravone 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 102769-77-7 [1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(5-methyl-2-phenyl-2H-pyrazol-3-yl)-amine 
• 141-97-9 ethyl acetoacetate 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 

Downstream Products

• 71237-21-3 [4-(4-dimethylamino-phenyl)-3,5-dimethyl-1-phenyl-1,4-dihydro-pyrano[2,3-c]pyrazol-6-yl]-diethyl-amine 
• 69157-82-0 (4-dimethylamino-phenyl)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-acetonitrile 

Relevant articles and documents

Iridium(III) complex-coated nanosystem for ratiometric upconversion luminescence bioimaging of cyanide anions

Chromophoric iridium(III) complex-coated NaYF4: 20%Yb, 1.6%Er, 0.4%Tm nanocrystals are demonstrated as a ratiometric upconversion luminescence (UCL) probe for highly selective detection of cyanide anion and bioimaging of CN- in living cells through inhibition of the energy transfer from the UCL of the nanocrystals to the absorbance of the chromophoric complex. The UCL probe provides a very low detection limit of 0.18 μM CN- in the aqueous solution.

Synthesis, crystal structure, Hirshfeld surface analysis, biological evaluation, DFT calculations, and in silico ADME analysis of 4-arylidene pyrazolone derivatives as promising antibacterial agents

The present paper describes an ultrasound-assisted synthesis of a series of 4-arylidene-1H-pyrazol-5(4H)-one derivatives (3a-i) catalyzed by sulfamic acid. The prepared compounds were characterized by physical and spectroscopic techniques and for compound

Synthesis of some pyrazolone derivatives and evaluation of its antibacterial and cytotoxic activity

A series of novel pyrazolone derivative were synthesized by two different schemes (scheme-1 by the reaction of phenyl hydrazine and ethyl acetoacetate with substituted benzaldehydes PYR-1 to PYR-4) and (by the reaction of synthesized chalcone with phenyl hydrazine PYR-5) and characterised with its physical parameters (M.P, colour, %yield, solubility etc.). The entire synthesized compound was tested for their antimicrobial activity against Grampositive and Gram-negative strains of bacteria and brimeshrimp bioassay was conducted for evaluation of cytotoxic activity The Investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good antimicrobial activity. And cytotoxicity activity of compounds was also found to be satisfactory.