2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

Base Information

Chemical Name:2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III
CAS No.:259522-70-8
Molecular Formula:C₃₈H₅₃ClO₁₁Si
Molecular Weight:749.371
Hs Code.:

Synonyms:2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

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Chemical Property of 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

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Technology Process of 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

There total 9 articles about 2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-03-8
propionyl chloride

: C₃₅H₄₉ClO₁₀Si

: 259522-70-8
2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00629-0

Reference yield:

: 994-30-9
triethylsilyl chloride

: 1134620-22-6
C₃₂H₃₉ClO₁₁

: 259522-70-8
2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.jfluchem.2008.05.013

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 259522-70-8
2-debenzoyl-2-(3-chlorobenzoyl)-7-triethylsilyl-10-deacetyl-10-propanoylbaccatin III

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / imidazole / dimethylformamide / 40 h / 20 °C

2: 97 percent / Red-Al / tetrahydrofuran / -10 °C

3: DIC; DMAP / CH₂Cl₂

4: HF*pyridine; pyridine / acetonitrile / 40 h / 20 °C

5: imidazole / dimethylformamide / 2 h / 20 °C

6: LiHMDS / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; pyridine hydrogenfluoride; dacarbazine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: silylation / 2: debenzoylation / 3: Esterification / 4: desilylation / 5: silylation / 6: Acylation;
DOI:10.1016/S0960-894X(99)00629-0