7-oxo-6,7-diphenylheptanenitrile

Base Information

• Chemical Name: 7-oxo-6,7-diphenylheptanenitrile
• CAS No.: 38940-44-2
• Molecular Formula: C₁₉H₁₉NO
• Molecular Weight: 277.366
• Mol file: 38940-44-2.mol

Synonyms:7-oxo-6,7-diphenylheptanenitrile

Chemical Property of 7-oxo-6,7-diphenylheptanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of 7-oxo-6,7-diphenylheptanenitrile

There total 5 articles about 7-oxo-6,7-diphenylheptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,2-diphenylprop-2-en-1-one (4452-11-3) + cyclobutanone oxime (2972-05-6) → 7-oxo-6,7-diphenylheptanenitrile (38940-44-2)

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; sodium carbonate; triphenylphosphine; In dichloromethane; at 20 ℃; for 120h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.9b00651

Reference yield: 56.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + cyclobutanone O-(4-(trifluoromethyl)benzoyl) oxime + benzaldehyde (100-52-7) → 7-oxo-6,7-diphenylheptanenitrile (38940-44-2)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dichloromethane; at 60 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03907

Reference yield: 54.0%

2-phenylcyclohexan-1-one O-(2,4-dinitrophenyl)oxime + benzaldehyde (100-52-7) → 7-oxo-6,7-diphenylheptanenitrile (38940-44-2)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-4,5,6,7-tetrahydrobenzo[d]thiazol-3-ium perchlorate; caesium carbonate; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.0c04248

upstream raw materials:

6-Chloro-1,2-diphenyl-hexan-1-one

sodium cyanide

phenyl benzyl ketone

1,2-diphenylprop-2-en-1-one