2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

Base Information

Chemical Name:2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate
CAS No.:1356116-56-7
Molecular Formula:C₁₂H₉F₆NO₄
Molecular Weight:345.198
Hs Code.:

Synonyms:2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

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Chemical Property of 2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

Chemical Property:

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Technology Process of 2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

There total 4 articles about 2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 75-89-8
2,2,2-trifluoroethanol

: 552-89-6
2-nitro-benzaldehyde

: 109-77-3
malononitrile

: 1356116-56-7
2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 3h; chemoselective reaction;
DOI:10.1039/c5cc03369a

Reference yield: 61.0%

: 75-89-8
2,2,2-trifluoroethanol

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1356116-56-7
2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

Guidance literature:: With [bis(acetoxy)iodo]benzene; at 20 ℃; for 16h;
DOI:10.1055/s-0035-1560990

Reference yield:

: 86451-26-5
2,2'-(phenyl-λ³-iodanediyl)bis(isoindoline-1,3-dione)

: 1356116-56-7
2,2,2-trifluoroethyl 2-(((2,2,2-trifluoroethoxy)carbonyl)amino)benzoate

: 653-96-3
anthranilic acid-(2,2,2-trifluoro-ethyl ester)

Guidance literature:: Multi-step reaction with 2 steps

1.1: [hydroxy(tosyloxy)iodo]benzene; potassium carbonate; sodium sulfate / acetonitrile / 6 h / 20 °C

2.1: iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid / 0.17 h / 0 °C / Inert atmosphere

2.2: 8 h / 0 - 40 °C / Inert atmosphere

With iodobenzene; [hydroxy(tosyloxy)iodo]benzene; potassium carbonate; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid; In acetonitrile; 1.1: Hofmann-type rearrangement / 2.2: Hofmann-type rearrangement;
DOI:10.1021/ol300028j