Carbamic acid, (3-methylenecyclobutyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (3-methylenecyclobutyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 130369-04-9
• Molecular Formula: C10H17NO2
• Molecular Weight: 183.25
• Hs Code.: 2924299090
• Mol file: 130369-04-9.mol

Synonyms:(3-Methylenecyclobutyl)carbamic acid tert-butyl ester;

Chemical Property of Carbamic acid, (3-methylenecyclobutyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Melting Point: 95-100°C
• Refractive Index: 1.474
• Boiling Point: 263.8 °C at 760 mmHg
• PKA: 12.22±0.20(Predicted)
• Flash Point: 113.3 °C
• PSA: 38.33000
• Density: 1 g/cm³
• LogP: 2.62060

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(3-Methylenecyclobutyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-methylenecyclobutyl)-, 1,1-dimethylethyl ester (9CI)

There total 9 articles about Carbamic acid, (3-methylenecyclobutyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

3-(tert-butyloxycarbonylamino)cyclobutan-1-one (154748-49-9) + Methyltriphenylphosphonium bromide (1779-49-3) → (3-methylene-cyclobutyl)-carbamic acid tert-butyl ester (130369-04-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at -20 - 0 ℃; for 0.5h;

3-(tert-butyloxycarbonylamino)cyclobutan-1-one; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 77.0%

3-methylenecyclobutane-1-carboxylic acid (15760-36-8) + tert-butyl alcohol (75-65-0) → (3-methylene-cyclobutyl)-carbamic acid tert-butyl ester (130369-04-9)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; Reflux;

Reference yield: 70.7%

3-(tert-butyloxycarbonylamino)cyclobutan-1-one (154748-49-9) + triphenylphosphine hydrobromide (6399-81-1) → (3-methylene-cyclobutyl)-carbamic acid tert-butyl ester (130369-04-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran;

upstream raw materials:

di-tert-butyl dicarbonate

3-methylenecyclobutane-1-carboxylic acid

3-methylenecyclobutylamine

3-methylenecyclobutanecarbonitrile

Downstream raw materials:

3-(tert-butyloxycarbonylamino)cyclobutan-1-one

(3-hydroxy-3-methyl-cyclobutyl)-carbamic acid tert-butyl ester

tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate

cis-3-[(tert-butoxycarbonyl)(methyl)amino]cyclobutyl methanesulfonate