2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

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Chemical Name:2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide
CAS No.:1607465-41-7
Molecular Formula:C₂₄H₁₈N₈S
Molecular Weight:450.527
Hs Code.:

Synonyms:2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

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Chemical Property of 2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

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Technology Process of 2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

There total 3 articles about 2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1607465-38-2
2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)acetamide

: 1607465-41-7
2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; at 85 ℃; for 12h; Sealed tube;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 614750-82-2
1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

: 1607465-41-7
2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 90 °C

1.2: 3 h / Reflux

2.1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; sodium hydride; sodium iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.03.022

Reference yield:

: 746667-09-4
6-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

: 1607465-41-7
2-(4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-(3-cyanophenyl)ethanethioamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; sodium hydride; sodium iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.03.022