4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1000771-51-6
• Molecular Formula: C₁₉H₂₇ClN₂O₃
• Molecular Weight: 366.888

Synonyms:4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (644981-94-2) + N,N-dimethylammonium chloride (506-59-2) → 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1000771-51-6)

Guidance literature:

4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester; N,N-dimethylammonium chloride; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (644981-94-2) + dimethyl amine (124-40-3) → 4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1000771-51-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

DOI:10.1016/j.bmcl.2007.09.092

Reference yield: 95.0%

4-(4-chlorophenyl)-4-dimethylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1000771-51-6) → 4-(4-chlorophenyl)-N,N-dimethylpiperidine-4-carboxamide (80139-82-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

DOI:10.1016/j.bmcl.2007.09.092

upstream raw materials:

4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

N,N-dimethylammonium chloride

dimethyl amine

Downstream raw materials:

4-(4-chloro-phenyl)-piperidine-4-carboxylic acid dimethylamide hydrochloride

4-(4-chlorophenyl)-N,N-dimethylpiperidine-4-carboxamide

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