6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

Base Information

Chemical Name:6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid
CAS No.:91586-45-7
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:

Synonyms:6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

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Chemical Property of 6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

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Technology Process of 6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

There total 5 articles about 6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 91586-29-7
Methyl 6-methoxy-2-(4-methoxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

: 91586-45-7
6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 10h;
DOI:10.1021/jo00195a033

Reference yield:

: 91586-26-4
1-(4-methoxybenzoyl)piperidin-4-one

: 91586-45-7
6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux

2: 91 percent / toluene / 24 h / 120 °C

3: 97 percent / 1.0N aqueous NaOH / methanol; tetrahydrofuran / 10 h / 25 °C

With sodium hydroxide; sodium acetate; acetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00195a033

Reference yield:

: 190012-08-9
1-(4-methoxybenzoyl)-4-piperidone ethylene ketal

: 91586-45-7
6-Methoxy-2-(4-methoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / 10percent aqueous H₂SO₄ / tetrahydrofuran / 20 h / 25 °C

2: 59 percent / 1) lithium diisopropylamide 2) acetic anhydride, sodium acetate / tetrahydrofuran / 1) a) 1h -78 deg C b) 3.75h -78 -> 25 deg C 2) 1h reflux

3: 91 percent / toluene / 24 h / 120 °C

4: 97 percent / 1.0N aqueous NaOH / methanol; tetrahydrofuran / 10 h / 25 °C

With sodium hydroxide; sulfuric acid; sodium acetate; acetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00195a033