(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Base Information

Chemical Name:(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone
CAS No.:1263265-93-5
Molecular Formula:C₂₅H₃₅N₃O₃S
Molecular Weight:457.637
Hs Code.:

Synonyms:(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

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Chemical Property of (9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Chemical Property:

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Technology Process of (9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

There total 3 articles about (9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 105753-26-2
3-(2-bromoethyl)-phenylethanol

: (2-isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone hydrochloride

: 1263265-93-5
(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: With potassium carbonate; In water; acetonitrile; at 20 - 60 ℃; for 66h; Product distribution / selectivity;

Reference yield:

: 46133-05-5
1,3-Bis(2'-hydroxyethyl)benzene

: 1263265-93-5
(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / toluene; water / 38 h / 87 °C / Reflux

2: potassium carbonate / acetonitrile; water / 66 h / 20 - 60 °C

With hydrogen bromide; potassium carbonate; In water; toluene; acetonitrile;

Reference yield:

: 19806-17-8
1,3-benzenediacetic acid

: 1263265-93-5
(9-(3-(2-hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / 2-methyltetrahydrofuran / 19.5 h / 31 - 50 °C

2: hydrogen bromide / toluene; water / 38 h / 87 °C / Reflux

3: potassium carbonate / acetonitrile; water / 66 h / 20 - 60 °C

With lithium aluminium tetrahydride; hydrogen bromide; potassium carbonate; In 2-methyltetrahydrofuran; water; toluene; acetonitrile;